Our goal in demonstrating high-power few-cycle THz sources is to advance solvation science by elucidating the microscopic dynamics of solvents, particularly water, in bulk and chemical reactions like protein folding. THz radiation, with photon energy of 1-10 THz, is ideal for probing water’s hydrogen bond network motions. While THz-TDS studies of liquids are growing, they mostly use linear techniques, offering limited dynamic information. Nonlinear THz spectroscopy is the next milestone but requires high-energy, high-repetition-rate THz sources. Current limitations include low pulse energy at high repetition rates or long measurement times at low repetition rates, especially for liquids due to weak nonlinear responses and strong absorption. To overcome these challenges, we use laboratory-based THz sources with high pulse energy (µJ class and above) and high repetition rate, driven by ultrafast near-infrared sources with high pulse energy (tens of mJ) and high average power (hundreds of watts).